How life generates new forms

When organisms change during the course of evolution, often what drives new forms is not genes themselves, but gene regulation — what turns genes on and off. A new study identifies the kind of gene regulation most likely to generate evolutionary change, according to Science Daily.

Most modern organisms store genetic information in DNA and transcribe the information from DNA into RNA. Protein “transcription factors” that inhibit or enhance transcription of genes in the DNA are said to regulate gene expression.

In a March paper, a team demonstrated that gene regulation by protein transcription factors more readily powers evolutionary change than another form of gene regulation that works at the RNA level.

 “That really surprised us,” said senior author Andreas Wagner. “It’s not self-evident. It’s one of those things you just don’t know before you look.”

“New forms of regulation are crucial for a lot of new features of life,” said Wagner. “What distinguishes the body plan of humans from that of sea urchins or fruit flies is new kinds of regulation — turning the right genes on and off at the right time.”

Previous work by the same team showed that transcription factors show high levels of two key evolutionary traits — robustness and evolvability. A robust system functions relatively normally even when mutations occur. In contrast, an evolvable system is able to generate new forms or traits in response to new mutations.

Added lead author Joshua Payne: “We find that transcription factor binding sites are highly evolvable because mutations often create binding sites for other transcription factors. In this way, mutations to transcription factor binding sites can readily bring forth phenotypic variation.”

The evolvability of transcriptional regulation may help explain why organisms switched from using RNA to store information some 4 billion years ago, to using DNA and proteins, Wagner said.

N.H.Kh