New insights into skin cells could explain why our skin doesn’t leak

The discovery of the shape and binding capability of epidermal cells could explain how skin maintains a barrier even when it is shedding according to Science daily.

The authors of the study say their new understanding of how epidermal cells form a barrier may explain the paradox of how we can shed them without compromising our skin’s integrity. It could also help us to understand what happens when it forms incorrectly, which could lead to conditions like psoriasis and eczema.

Humans lose 200,000,000 skin cells every hour. During a 24-hour period, a person loses almost five thousand million skin cells. It has been a challenge for scientists to explain how this colossal shedding process can occur without there being a break in the skin barrier.

Scientists have previously known the epidermis consists of a thick outer barrier of dead epidermal cells, which are constantly shedding. What they’ve known less about is a secondary barrier deeper below the surface in the epidermis that is made up of only a single layer of cells, which forms a much thinner, though no less important, protective barrier.

Now, a team, have discovered that the shape of the epidermal cells combined with their ability to temporarily glue together, may explain how they form this strong barrier.

The researchers suggest that a shape of an epidermal cell is actually a flattened version of a tetrakaidecahedron — a 14-sided 3D solid made out of six rectangular and eight hexagonal sides. The authors came to their conclusion after studying skin cells in mouse models using a confocal and two-photon microscopes, and developing mathematical models.

The tetrakaidecahedron shape was first proposed in 1887 by William Thomson (Lord Kelvin), a mathematical physicist and engineer. He claimed that the tetrakaidecahedron was the best shape for packing equal-sized objects together to fill space with minimal surface area.

The team in today’s study say the epidermal cells’ unique tetrakaidecahedron-like geometry means that it can always form a very tight, cohesive bond with the epidermal cells surrounding it. This is because the mix of rectangular and hexagonal sides enables the cell to always be tightly connected to the cells surrounding it.

The team also discovered that these cells manufacture proteins, which act as a temporary glue that binds the cells together in what are called ‘tight junctions’. The combination of the cells’ geometry and tight junction formation means that the skin barrier can maintain its integrity even though it is very thin.

When new cells underneath form the new tight junctions, this pushes the older cells upwards towards the surface of the skin, and the older cells lose their tight junctions. In this way, the tight junction barrier in the cell sheet is always maintained.

The team suggest that ‘malfunctions’ in the production of the tight junctions may be a contributing factor that explains why some people have conditions such as eczema, where the skin barrier is weakened, which leads to bacterial infiltration, inflammation, scratching and further infection. In other cases, fails in the interlocking barrier between cells — the tight junctions — may partly explain why in psoriasis there is an overproduction of epidermal cells, causing thick patches of skin on the surface.

Dr Reiko Tanaka, one of the study’s authors, said: “It is amazing to think that an abstract concept for a shape devised by the mathematician Lord Kelvin over a century ago may be an important shape in nature, helping our skin to maintain its effectiveness as barrier.

“Our study is also helping us to see how the cells that make up our skin can switch on a mechanism to make a kind of glue, which binds the cells together, ensuring that our skin maintains its integrity.

“Our skin is the largest organ in our body and it is vital that we completely understand how it works, so when it doesn’t work as it should, such as in eczema or psoriasis, we can understand the mechanisms that might be causing the problems.”

The next steps will see the team analysing how skin thickness is determined and how the balance between cell growth and cell shedding is maintained. Faults in this process can lead to a thickening of the skin, leading to conditions like psoriasis. The team will also determine why skin thins as we get older, providing new insights into aging, or when it thins because special treatments like steroids are administered to treat eczema.

 

N.H.Kh

 

You might also like
Latest news
58 martyrs in Israeli aggression on several Lebanese areas Israeli aggression targets Josieh crossing on the Syrian-Lebanese borders 120 Palestinians martyred in seven Israeli massacres during the past 24 hours Sabbagh congratulates Attaf on renewal of confidence as Algerian Foreign Minister A solidarity event in Moscow for the Arab peoples in the face of Zionist attacks and crimes President Al-Assad accepts credentials of new Ambassador of South Africa Workshop about situation of the Financing Market for Micro and Small Enterprises kicks off Four martyred in initial toll in Israeli occupation new raid on Beirut city center Syria, Cuba discuss promoting trade ties Syria Receives Two Gold and Two Silver Medals at The Arab Kickboxing Tournament in Egypt   Terrorist Ben-Gvir Storms Ibrahimi Mosque in Hebron “China's Views-The Syrian War and Europe” a Book by Chinese Researchers Translated by Safwan Bahloul Yemeni Forces Target an Israeli Enemy Base South of Occupied Palestine with a Ballistic Missile UN Calls for Accountability of Those Responsible for Targeting Humanitarian Workers in Gaza and Leba... Russia Strongly Condemns Israel's Aggression Against Palmyra... It is a Flagrant Violation of Syrian... 25 Martyrs and Dozens Wounded in the Occupation Bombing of Various Areas of the Gaza Strip Three European Countries Announce their Readiness to Arrest Netanyahu and Gallant if They are on The... Organization of Islamic Cooperation: Issuing Arrest Warrants Against Netanyahu and Gallant Contribut... The Feature Film (Temporary Darkness) Participates in The Hague Film Festival in the Netherlands Syrian Doctor Receives Best Clinical Presentation at Diabetic Foot Conference in Los Angeles