Benefits of a healthy diet greater in people at high genetic risk for obesity

The benefits of sticking to a healthy diet to prevent long term weight gain are greater in people at high genetic risk for obesity than in those with low genetic risk, according to Science Daily

The researchers say their findings indicate that improving diet quality over time might lead to greater weight loss for people who are genetically susceptible to obesity. The study also indicates that the genetic risk of weight gain is attenuated by improving diet quality.

Obesity is a complex disorder involving a mix of genes and environmental influences. Previous research has shown that diets high in sugar sweetened drinks and fried foods could amplify the genetic associations with higher body weight.

 But could following a diet rich in fruit and vegetables and low in processed foods diminish the genetic association with weight gain? And could the benefits of a healthy diet pattern on weight loss be the same for people with a distinct genetic susceptibility to obesity?

To investigate further, Dr Lu Qi, Professor of Epidemiology, and other researchers, analysed data from two large studies health professionals — 8,828 women and 5,218 men.

Genetic risk score was calculated using 77 gene variants associated with body mass index. Changes in body mass index and weight were calculated every four years.

Changes in dietary patterns were also assessed every four years using three diet quality scores These diets are all rich in fruit and vegetables, nuts and whole grains and low in salt, sugary drinks, alcohol and red and processed meats.

After 20 years of follow-up, the researchers found that improving adherence was associated with decreases in body mass index and body weight — and that the effect was more prominent in people at high genetic risk for obesity than those with low genetic risk. In addition, they note that “the genetic risk of weight gain is attenuated by improving adherence to these healthy dietary patterns.

The authors point out that this is an observational study, so no firm conclusions can be drawn about cause and effect. They also acknowledge several limitations including the influence of unmeasured factors, such as physical activity.

Nevertheless, they say their findings “highlight the importance of improving adherence to a healthy diet in the prevention of weight gain, particularly in people genetically predisposed to obesity.”

This study underlines the critical importance of achieving healthy diets for everyone, say researchers, though they acknowledge that this is still a challenge for many.

As with many genetic association studies, the effect of genetic predisposition was small, they write. However the findings “do provide encouraging new evidence that whilst a better diet can improve weight loss, the impact may be greatest in those with the highest genetic predisposition for obesity.”

They argue that “genetic predisposition is no barrier to successful weight management and no excuse for weak health ” and say people “must act to ensure universal healthy diets within health-promoting food environments and food systems.”

N.H.Kh