Air temperature is external trigger for heart attack

A 16 year study in more than 280,000 patients has suggested that air temperature is an external trigger for heart attack according to Science daily.

“There is seasonal variation in the occurrence of heart attack, with incidence declining in summer and peaking in winter,” said first author Dr Moman A. Mohammad. “It is unclear whether this is due to colder temperatures or behavioural changes.”

This nationwide, 16 year, observational study led by Prof David Erlinge, is the largest to investigate the association between heart attack incidence and weather conditions such as air temperature, sunshine duration, precipitation, and air pressure.

The investigators studied the specific weather conditions during which heart attacks occurred using meteorological data from hundreds of weather stations.

The average daily minimum temperature was calculated as <0 °C, 1-10 °C and >10 °C. The relationship between the average number of heart attacks per day and the average minimum air temperature was evaluated.

During the study period, a total of 280,873 heart attacks occurred of which meteorological data were available for 99%. The average number of heart attacks per day was significantly higher during colder temperatures as compared to warmer. The results were consistent across healthcare regions.

On a day-to-day basis, this translated into four more heart attacks when the average daily temperature was less than 0 °C as compared to when it was above 10°C. Furthermore, the occurrence of heart attacks was increased with higher wind velocities, limited sunshine duration and higher air humidity. Consistent results were observed in ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction.

The investigators analysed the relationship between heart attack incidence and weather conditions in subgroups including the elderly, those with hypertension, diabetes mellitus or previous heart attacks, and patients taking various medications. The link between heart attack incidence and weather conditions was stable across subgroups.

Dr Mohammad said: “Our results consistently showed a higher occurrence of heart attacks in sub-zero temperatures. The findings were the same across a large range of patient subgroups, suggesting that air temperature is a trigger for heart attack.”

The body responds to cold by constricting superficial blood vessels, which decreases thermal conduction in the skin and subsequently increases arterial blood pressure. Other responses are shivering and increased heart rate, which raise the metabolic rate and in turn increase body temperature.

“In the majority of healthy people these mechanisms are well tolerated,” said Dr Mohammad. “But in people with atherosclerotic plaques in their coronary arteries they may trigger a heart attack.”

As this was an observational study, Dr Mohammad said there were other factors that may have contributed to the results. He said: “Respiratory tract infections and influenza are known risk factors for heart attack that have a clear seasonal variation. In addition, seasonal-dependent behaviours such as reduced physical activity and dietary changes could play a role in the increased occurrence of heart attack during colder weather.”

N.H.Kh