Low vitamin B12 levels may lead to brain shrinkage, cognitive problems
Older people with low blood levels of vitamin B12 markers may be more likely to have lower brain volumes and have problems with their thinking skills.
Foods that come from animals, including fish, meat, especially liver, milk, eggs and poultry are usual sources of vitamin B12.
The study involved 121 older residents .The 121 participants had blood drawn to measure levels of vitamin B12 and B12-related markers that can indicate a B12 deficiency. The same subjects took tests measuring their memory and other cognitive skills.
An average of four-and-a-half years later, MRI scans of the participants’ brains were taken to measure total brain volume and look for other signs of brain damage.
Having high levels of four of five markers for vitamin B12 deficiency was associated with having lower scores on the cognitive tests and smaller total brain volume.
“Our findings definitely deserve further examination,” said Christine C. Tangney, PhD, associate professor, and lead author of the study. “It’s too early to say whether increasing vitamin B12 levels in older people through diet or supplements could prevent these problems, but it is an interesting question to explore. Findings with B vitamin supplementation are also supportive of these outcomes.”
On the cognitive tests, the scores ranged from -2.18 to 1.42, with an average of 0.23. For each increase of one micromole per liter of homocysteine — one of the markers of B12 deficiency — the cognitive scores decreasedby 0.03 standardized units or points.
Tangney noted that the level of vitamin B12 itself in the blood was not associated with cognitive problems or loss in brain volume. She said that low vitamin B12 can be difficult to detect in older people when looking only at blood levels of the vitamin.
“Our findings lend support for the contention that poor vitamin B12 status is a potential risk factor for brain atrophy and may contribute to cognitive impairment,” said Tangney.
Source: Science daily
N.H.Khider