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Zinc in the body may contribute to kidney stones

New research on kidney stone formation reveals that zinc levels may contribute to kidney stone formation, a common urinary condition that can cause excruciating pain. The research found that zinc may be the core by which stone formation starts.

The study, opens a new perspective into the cause of urinary stones and related diseases and might ultimately lead to the identification of new preventive and therapeutic approaches.

"The ultimate goal of our research team is to prevent kidney stones from happening in the first place and to understand the mechanisms by which they form a part of that effort," said lead author Thomas Chi, MD, an assistant professor of medicine. Chi has worked extensively on developing a fruit fly model of kidney stones.

 

Kidney stones are hard, often jagged masses of crystalized minerals that form in the kidney. Although stones can be small, their passage can result in significant pain and are the reason that more than half a million people go to emergency rooms annually.

The fruit fly produces stones similar to those in humans and has proven to be an excellent model for exploring risk factors for stones in humans. In the study conducted scientists decided to look within humans and the flies  to explore the interplay of zinc with oxalate, calcium and other minerals that make up kidney stones.

"The idea made sense, because our most recent research demonstrates that zinc is important for the mineralization and calcification processes that lead to urinary stones," said Chi.

The findings showed that changes in oxalate levels in the urine, which is a known risk factor for kidney stones, tracked well with dietary zinc intake: as zinc dropped, urinary oxalate changed dramatically.

"Possible causes include drinking too little water, exercise (too much or too little), obesity, weight loss surgery, or eating food with too much salt or sugar,". Infections and family history can also lead to kidney stones.

"Once you have developed a first stone, as many as 50 percent of people are at risk of developing another stone within five years," said Chi. "Amazingly, we have not had a new medication for the prevention of kidney stones in more than 25 years, and the medications that we do have aren't completely effective."

Source :Science daily

N.H.Kh

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